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Correlation Analysis

In this panel, you can compute the correlation of two genes or two signatures in multiple cancer types and tissues. Some gene signature lists are provided.

This function performs pair-wise gene expression correlation analysis for given sets of TCGA and/or GTEx expression data, using methods including Pearson, Spearman and Kendall.

Parameters:

  • Gene A: Input a gene/isoform or gene signature A of interest. [For x-axis]
  • Gene B: Input a gene/isoform or gene signature B of interest. [For y-axis]
  • Log2 (TPM+1) Scale Choose to use log2(TPM+1) transformed expression, while using TPM.
  • Correlation Coefficient: The method for calculating the correlation coefficient.
  • TCGA Tumor/TCGA Peritumor/GTEx Normal, Used Expression Datasets: Select cancer types of interest in the "TCGA Tumor", "TCGA Peritumor" or "GTEx Normal" field and click "add" to build dataset list in the "Selected Datasets" field. Also, manual input of cancer types split by comma (e.g. COAD Tumor,READ Tumor) is also acceptable. The correlation analysis is based on the datasets list.

Note: always use log-scale axis for visualization, regardless of whether calculated on log-scale.

Tips: Ctrl/Command + A: select all cancer types

TCGA Abbr.
Abbr Detail
ACC Adrenocortical carcinoma
BLCA Bladder Urothelial Carcinoma
BRCA Breast invasive carcinoma
CESC Cervical squamous cell carcinoma and endocervical adenocarcinoma
CHOL Cholangiocarcinoma
COAD Colon adenocarcinoma
DLBC Lymphoid Neoplasm Diffuse Large B-cell Lymphoma
ESCA Esophageal carcinoma
GBM Glioblastoma multiforme
HNSC Head and Neck squamous cell carcinoma
KICH Kidney Chromophobe
KIRC Kidney renal clear cell carcinoma
KIRP Kidney renal papillary cell carcinoma
LAML Acute Myeloid Leukemia
LGG Brain Lower Grade Glioma
LIHC Liver hepatocellular carcinoma
LUAD Lung adenocarcinoma
LUSC Lung squamous cell carcinoma
MESO Mesothelioma
OV Ovarian serous cystadenocarcinoma
PAAD Pancreatic adenocarcinoma
PCPG Pheochromocytoma and Paraganglioma
PRAD Prostate adenocarcinoma
READ Rectum adenocarcinoma
SARC Sarcoma
SKCM Skin Cutaneous Melanoma
STAD Stomach adenocarcinoma
TGCT Testicular Germ Cell Tumors
THCA Thyroid carcinoma
THYM Thymoma
UCEC Uterine Corpus Endometrial Carcinoma
UCS Uterine Carcinosarcoma
UVM Uveal Melanoma

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