In this panel, you can compare gene/signature expression level between patients with different drug responses annotated in TCGA.

GEPIA performs differential expression analysis (ANOVA or Wilcoxon) with patients in four drug response groups (CR/PR/SD/PD).

Parameters:

• Gene: Input a gene/isoform or gene signature A of interest.
• Methods: Select ANOVA or Wilcoxon for differential analysis.
• log2 transformed: Select whether use log2(TPM+1) as expression abundance.
• Datasets Selection: Select one or multiple cancer types of interest in the "Dataset Selection" field and click "add" to build dataset list in the "Datasets" field.
• Groups: Choose which group to compare

Results:

• The table shows the results of differential expression analysis for gene expression levels between patients with different drug responses. Click the button beside drug names to plot the detailed expression distribution of the four response groups with the drug.

Notices:

• Both drug generic name and trade name are provided. See drug name standarization rules.
• Since special treatment of blood tumor are not included (e.g. stem cell transplantation in DLBC), be careful to combine blood tumor and solid tumor into a uniformed dataset.
• Notice that there may not be sufficient cases for survial anaysis in single or limited cancer types.