In this panel, you can explore the interaction relationships of genes based on selected datasets and interaction types. STRING database annotations can also be optionally included.

This function integrates data sources such as TCGA expression data, co-mutation and mutually exclusive mutation patterns, synthetic lethality/viability interactions, and oncogenic protein-protein interactions. Pairwise correlations and specific interaction types can be visualized as interactive networks and summarized in tables.

GEPIA3 uses the log-scale for expression calculation. Only edges (pairwise interactions) information will be listed below. If you are interested in exploring all relationships for a specific gene, please use the corresponding analysis modules provided.
When searching, the displayed network highlights the top k (Nodes Displayed input) nodes with the highest degrees connected to the target gene within the selected datasets and interaction patterns.

Parameters:

• Gene: Input a gene/isoform or multiple genes of interest.
• Interaction Pattern: Select one or more gene interaction patterns of interest.
• Nodes Display: Specify the number of nodes to be displayed on the graph.
• TCGA Tumor/Selected Datasets: Select cancer types of interest in the "TCGA Tumor" field and click "add" to build dataset list in the "Selected Datasets" field. Also, manual input of cancer types split by comma (e.g. COAD Tumor,READ Tumor) is also acceptable. The interaction analysis is based on the datasets list.

Notes:

• Only gene pairs with an absolute Pearson Correlation Coefficient (PCC) greater than 0.5 are considered in the analysis of expression patterns.